Vanillic Acid Ameliorates Diethyl Phthalate and Bisphenol S -Induced Cardiotoxicity in rats via abrogating oxidative Stress.
Keywords:Bisphenol S, diethyl phthalate, vanillic acid, cardiotoxicity, oxidative stress
Background: Neglected home producing toxicants (NHPT) are the endocrine disruptors affecting biological systems. We investigated the effect of vanillic acid on diethyl phthalate (DEP) and bisphenol S (BPS)-induced cardio-toxicity and oxidative stress using rat model.
Methods: Rats were exposed to DEP (50 mg/kg) and BPS (50 mg/kg) and treated with vanillic acid (25 and 50 mg/kg) by oral gavage for twenty-one days. Afterwards, they were sacrificed.
Results: Vanillic acid treatment significantly (p < 0.05) protected cardiac tissues architecture by abolishing the DEP+BPS-induced decrease in the activity of all the enzymatic antioxidants. Co-treatment with vanillic acid remarkably (p < 0.05) reversed DEP+BPS-induced decreases in glutathione levels, GSH, CAT, GPx, and SOD activities in cardiac tissues, while attenuating DEP+BPS mediated increase in cardio-oxidative damage markers (MDA,AOPP, and NO as well as increase activity of arginase and PDE-5.
Conclusion: Vanillic acid may have exert a cardio-protective effect against DEP+BPS induced cardiotoxicity by decreasing oxidative stress via its antioxidant, free radical scavenging effect.
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