Evaluation of Acute Dermal Toxicity and Acute Oral Toxicity of Neurovoral<sup>®</sup>Cream and Tea Extract in Rats
DOI:
https://doi.org/10.51412/psnnjp.2025.38Keywords:
dermal toxicity, erythema, hyperemia, tea extract, Traditional African MedicineAbstract
Herbal products have become a common remedy used in treatment and management of many diseases. The safety ascribed to natural products because of their origin is now doubtful as side effects and toxicities have been recorded. The aim of the study is to determine acute dermal toxicity and acute oral toxicity of Neurovoral® cream and tea extract.
Thirty albino rats were used to investigate the acute dermal toxicity (12) and acute oral toxicity (18) of Neurovoral® cream and tea respectively. Neurovoral® cream (0.5 g) was applied to the trimmed dorsal area of the trunk of rats, signs of toxicity (erythema, oedema, irritation) were observed periodically at 24, 28 and 72 h, and again after 14 days. The extract from the tea was administered at 2000 and 5000 mg/kg, and the rats were observed for the first 6 hours, and there after daily for 14 days. th All the animals were euthanised at the 14 day and vital organs (skin, kidney, liver, brain) were collected for subsequent histological analysis. Dermal toxicological report showed negligible erythema during the period of application of cream, and acute oral administration of 5000 mg/kg did not result in death or any significant toxicity signs. There was no significant alteration in the histology of organs observed. The study results indicated that Neurovoral® cream and tea are relatively safe and non-toxic to rats in acute exposure.
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