Prevalence and Antibiogram of Healthcare-Associated Methicillin-Resistant <i>Staphylococcus aureus</i> (HA-MRSA) in a Public Tertiary Healthcare Facility (NH) in Enugu, Enugu State, Nigeria.
DOI:
https://doi.org/10.51412/psnnjp.2025.41Keywords:
MRSA, HA-MRSA, antibiotic resistance, antibiotics, MARI, clinical samples, gentamycinAbstract
Methicillin Resistant Staphylococcus aureus (MRSA) remains a major cause of both community and healthcare-associated infections. This study was designed to determine the prevalence and antibiogram of healthcare-associated MRSA(HA-MRSA) in a public tertiary healthcare facility (NH) in Enugu, Enugu State, Nigeria. A total of 62 {(male-33; female- 29) clinical samples were obtained from NH in Enugu State. S. aureus was isolated, characterized and identified based on standard microbiological procedures. Antibiograms of isolated MRSA isolates were determined by the KirbyBauer disc diffusion technique according to the Clinical Laboratory Standards Institute (CLSI) guidelines. The prevalence of MRSA was higher amongst the isolates obtained from males (48.5%) than females (41.4%). The highest prevalence of MRSA in relation to age and sample source were obtained from {(31-45) and (46-60)} years and urine as (66.7%) and (42.6%), respectively. HAMRSA were highly resistant to penicillin (100%), tetracycline (95.6%), and erythromycin (95.6%), but moderately susceptible to gentamycin and ciprofloxacin. A mean multiple antibiotic resistance index (MARI) of 0.8 was observed in this study with 96% > 0.2. In conclusion, prevalence of HAMRSA was high in the study area and there is a need for more proactive measures to curb this public health menace before it escalates beyond control.
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