Attenuation of Bleomycin-induced Toxicity on Selected Respiratory Function Metrics in Rabbits by a Polyherbal Preparation

Authors

  • Kennedy I. Amagon Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Kakjing D. Falang Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Bukata B. Bukar Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Jacob A. Kolawole Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Ukpe Ajima Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • James G. Damen Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Yusuf Agabi Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Richard J. Kutshik Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Ishaya Y. Longdet Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Simji Gomerep Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Ismaila Shittu Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Stephen D. Davou Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
  • Noel N. Wannang Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

DOI:

https://doi.org/10.51412/psnnjp.2024.07

Keywords:

Bleomycin, Lung function, Polyherbal preparation, Toxicity
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Abstract

Introduction: Bleomycin, a commonly used chemotherapeutic agent, is known for its potential to induce respiratory toxicity. Despite its efficacy in treating various cancers, its use is limited by adverse effects, including pulmonary complications. These respiratory disorders and diseases can significantly impact an individual's quality of life, leading to various health complications.

Objective: The study assessed the effect of a polyherbal preparation (CoV Pla-2 extract) on tidal volume (V ), vital capacity (VC), inspiratory capacity (IC) and inspiratory reserve volume (IRV) T following bleomycin-induced lung injury in rabbits.

Methods: Lung injury was induced in rabbits using bleomycin administered via oropharyngeal aspiration. Animals were randomly divided into six groups of three rabbits each and received treatments as follows: Group 1: Normal Saline (5 ml/kg); Group 2: Bleomycin (4 U/kg); Group 3: CoV Pla-2 extract (125 mg/kg) and Bleomycin (4 U/kg); Group 4: CoV Pla-2 extract (500 mg/kg) and Bleomycin (4 U/kg); Group 5: CoV Pla-2 extract (125 mg/kg); Group 6: CoV Pla-2 extract (500mg/kg). Normal saline and the extract were administered daily for 14 days per oral, while Bleomycin was administered on days 0 and 2. Adigital spirometer was used to monitor some pulmonary function parameters.

Results: Results showed that administration of bleomycin decreased Inspiratory Capacity, Vital Capacity, Inspiratory Reserve Volume and Tidal Volume when compared to control. Coadministration of the extract and bleomycin caused an increase in these pulmonary function parameters, when compared to the animals administered bleomycin alone. Conclusion: The findings from this study suggest that CoV Pla-2 extract can modify bleomycin-induced lung injury, as seen in increase in Tidal Volume, Vital Capacity, Inspiratory capacity and Inspiratory Reserve Volume following injury due to bleomycin.

Author Biographies

Kennedy I. Amagon, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.

Kakjing D. Falang, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.

Bukata B. Bukar, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.

Jacob A. Kolawole, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmaceutical & Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Jos,
Nigeria.

Ukpe Ajima, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmaceutical & Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Jos,
Nigeria.

James G. Damen, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, University of Jos,
Nigeria.

Yusuf Agabi, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Virology Unit, Department of Microbiology, Faculty of Natural Sciences, University of Jos, Nigeria.

Richard J. Kutshik, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Jos, Nigeria.

Ishaya Y. Longdet, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Jos, Nigeria.

Simji Gomerep, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Infectious Diseases Unit, Department of Medicine, Faculty of Clinical Sciences, University of Jos, Nigeria

Ismaila Shittu, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

National Veterinary Research Institute, Vom, Plateau State, Nigeria.

Stephen D. Davou, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Plateau State Ministry of Health, Jos, Plateau State, Nigeria.

Noel N. Wannang, Plateau State Research Team on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.

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Published

2024-04-30

How to Cite

Amagon, K. I., Falang, K. D., Bukar, B. B., Kolawole, J. A., Ajima, U., Damen, J. G., … Wannang, N. N. (2024). Attenuation of Bleomycin-induced Toxicity on Selected Respiratory Function Metrics in Rabbits by a Polyherbal Preparation. The Nigerian Journal of Pharmacy, 58(1), 59–67. https://doi.org/10.51412/psnnjp.2024.07