Quality Assessment of Some Brands of Ciprofloxacin and Levofloxacin Tablets Circulating in Karu Local Government Area of Nasarawa state, Nigeria.



  • Olubunmi J. Olayemi Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria https://orcid.org/0000-0001-5759-7176
  • Pelumi O. Olawepo Department of Pharmaceutics and Pharmaceutical Technology, Bingham University, Karu, Nasarawa State, Nigeria
  • John Alfa Department of Pharmaceutics and Pharmaceutical Technology, Bingham University, Karu, Nasarawa State, Nigeria


Interchangeable, Similarity Factor, Tablet Brands, Levoflfloxacin, Ciproflfloxacin


Background: Circulation of poor-quality drugs has dire consequences on the health of consumers. Introduction of branded generics  to ensure availability and affffordability has shown potential for spread of poor-quality drugs. In this study, quality assessment of some  commonly marketed ciproflfloxacin (500 mg) and levoflfloxacin (500 mg) tablet brands in Karu Local Government Area (LGA) of  Nasarawa State, Nigeria was evaluated. 

Methods: Five tablet brands including an innovator, of either drug were sourced from 5 difffferent Pharmacies in the LGA. Tablets  were coded A1-A5 and B1-B5 for ciproflfloxacin and levoflfloxacin brands respectively. Physical assessment of the tablets was done.  Physico-mechanical properties, uniformity of weight, friability and disintegration time were also evaluated using pharmacopeia  methods. In vitro dissolution was carried out and the profifiles statistically analyzed using the similarity  and  difffference factors in comparison with the innovator products. 

Results: All the tablets had uniform weights within offiffifficial  specifification, diameter was between 16.37 and 19.44 mm. Friability  values were between 0.01 and 0.06 %; within specifification. Disintegration time for ciproflfloxacin and levoflfloxacin tablets was within  1.23 - 7.20 min and 3.19 - 12.90 min respectively; all met the specifification. All (100 %) the ciproflfloxacin brands met pharmacopeia requirement for drug release while only 60 % of the levoflfloxacin brands met this requirement.  Comparatively A4 with  f2 value of 41.62 % may not be interchangeable with the innovator brand while brands B2 and B4 with f2 values of 53.40 and 53.03 %  respectively may be interchanged with the innovator brand or with each other. 

Conclusion:All the tablet brands were found to have good mechanical properties but only 75 % of the ciproflfloxacin and 50 % of the  levoflfloxacin tablet brands were found to be interchangeable with the innovator drug brands. This calls for concern as it brings to  question the possible interchangeability of these brands with the innovator.  

Author Biography

Olubunmi J. Olayemi, Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria

Department of Pharmaceutics and Pharmaceutical Technology, Bingham University, Karu, Nasarawa State,



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How to Cite

Olayemi, O. J., Olawepo, P. O., & Alfa, J. (2023). Quality Assessment of Some Brands of Ciprofloxacin and Levofloxacin Tablets Circulating in Karu Local Government Area of Nasarawa state, Nigeria.: https://doi.org/10.51412/psnnjp.2023.17. The Nigerian Journal of Pharmacy, 57(1), 570–581. Retrieved from https://psnnjp.org/index.php/home/article/view/451