Formulation and evaluation of capsules and suppositories containing Gongrenema Latifolium
Keywords:
Capsules, Suppositories, Gongronema latifolium, Anti-diabetic, C-peptideAbstract
Introduction: Earlier studies have been done on Gongronema latifolium (GL) for anti-diabetic effect using animal model. However, the extracts have bitter taste. This study focused on the formulation and evaluation of solid dosage forms namely capsules and suppositories.
Method: Purified GL were used in formulation of capsules and suppositories.The capsules were evaluated for various physico-chemical properties such as weight uniformity, disintegration time and dissolution test. Physical properties of suppositories were also assessed. Investigation on anti-diabetic effects of capsules and suppositories of purifified Gongronema latifolium on Streptozotocin-induced diabetic rats was carried out.
Results: Weight uniformity tests of the capsules showed percentage deviation of less than 10%. Disintegration of the capsules was within 2 min. Drug release profile showed that peak drug release occurred at 12 min. Physical properties of suppositories were satisfactory. The antidiabetic effect of capsules was 52+ 11.82 %. C-peptide (pM) of GL purifified capsules was 115.76 +1.54 respectively. Blood glucose of diabetic guinea pig was not significantly reduced when varying concentrations of GL suppositories were administered.
Conclusion: Capsules and suppositories passed compendia requirements, while purifified Gongronema latifolium capsules demonstrated signifificant anti-diabetic activities unlike the suppositories. Suppository is not an ideal dosage form for Gongronema latifolium anti-diabetic herb.
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