Formulation and evaluation of capsules and suppositories containing Gongrenema Latifolium

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Ngozi Dorathy Udem
Michael Umale Adikwu
Moses Nkechukwu Ikegbunam
Samuel Chukwuneke Udem


Introduction: Earlier studies have been done on Gongronema latifolium (GL) for anti-diabetic effect using animal model. However, the extracts have bitter taste. This study focused on the formulation and evaluation of solid dosage forms namely capsules and suppositories.

Method: Purified GL were used in formulation of capsules and suppositories.The capsules were evaluated for various physico-chemical properties such as weight uniformity, disintegration time and dissolution test. Physical properties of suppositories were also assessed. Investigation on anti-diabetic effects of capsules and suppositories of purifified Gongronema latifolium on Streptozotocin-induced diabetic rats was carried out.

Results: Weight uniformity tests of the capsules showed percentage deviation of less than 10%. Disintegration of the capsules was within 2 min. Drug release profile showed that peak drug release occurred at 12 min. Physical properties of suppositories were satisfactory. The antidiabetic effect of capsules was 52+ 11.82 %. C-peptide (pM) of GL purifified capsules was 115.76 +1.54 respectively. Blood glucose of diabetic guinea pig was not significantly reduced when varying concentrations of GL suppositories were administered.

Conclusion: Capsules and suppositories passed compendia requirements, while purifified Gongronema latifolium capsules demonstrated signifificant anti-diabetic activities unlike the suppositories. Suppository is not an ideal dosage form for Gongronema latifolium anti-diabetic herb.

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How to Cite
Dorathy Udem, N. ., Umale Adikwu, M. ., Nkechukwu Ikegbunam, M. ., & Chukwuneke Udem, S. . (2021). Formulation and evaluation of capsules and suppositories containing Gongrenema Latifolium. The Nigerian Journal of Pharmacy, 55(2), 35–43 | Retrieved from
Author Biographies

Ngozi Dorathy Udem, Department of Pharmacy,

University of Nigeria Teaching Hospital Ituku Ozalla Enugu State Nigeria


Michael Umale Adikwu, Department of Pharmaceutics,

Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu State Nigeria

Moses Nkechukwu Ikegbunam, Department of Pharmaceutical Microbiology and Biotechnology,

Faculty of Pharmaceutical Sciences, Nnamdi Azkiwe University Awka Anambra State Nigeria

Samuel Chukwuneke Udem, Department of Veterinary Physiology and Pharmacology,

Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State Nigeria


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