Hepatoprotective effect of the ethanolic leaf extract of Carissa edulis (vahl) apocynaceae on carbon tetrachloride induced liver toxicity in rats



Carissa edulis, hepatoprotective, biochemical parameters, hepatocellular


Background: There are claims by herbalist and even indigenes of Plateau state on the efficient use of Carissa edulis in the management of liver diseases. This work was aimed at assessing these claims to determine the hepatoprotective effects ofCarissa edulis.

Methods: The ethanolic leaf extract of Carissa edulis was scrutinized for hepatoprotective activity against Carbon tetrachloride (CCl4 ) induced liver damage. Biochemical parameters were studied to assess the hepatoprotective activity of the ethanolic extract in serum. Total Bilirubin, Total Protein, Albumin, Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase, Total Cholesterol, Triglyceride and High-Density Lipoprotein were determined to assess the effect of the extract on CCl4 induced hepatic damage. Other test conducted include, liver antioxidant test like glutathione, malondialdehyde, superoxide dismutase, catalase and histopathological assessment of liver sections..

Results: The markers in the animals treated with CCl4 showed elevated concentration indicating severe hepatic damage by CCl4. A significant decrease in serum markers was observed in rats treated with plant extract signifying the effect of the plant extract in restoring normal functional ability of the hepatocytes.

Conclusion: These results imply that the ethanolic leaf extract of Carissa edulis has a protective effect against CCl4 induced hepato-cellular injury.

Author Biographies

Yocy Yohana Izam, Department of Pharmacology,

Faculty of Pharmaceutical Sciences, University of Jos.

John Chinenye Aguiyi, Department of Pharmacology,

Faculty of Pharmaceutical Sciences, University of Jos


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How to Cite

Yohana Izam, Y. ., & Chinenye Aguiyi, J. . (2021). Hepatoprotective effect of the ethanolic leaf extract of Carissa edulis (vahl) apocynaceae on carbon tetrachloride induced liver toxicity in rats. The Nigerian Journal of Pharmacy, 55(2), 15–23 | https://doi.org/10.51412/psnnjp.2021.9. Retrieved from https://psnnjp.org/index.php/home/article/view/87