Evaluation Of Some Selected Brands of Iron Containing Liquid Preparations Marketed In Ilorin, Kwara State
https://doi.org/10.51412/psnnjp.2023.27
Keywords:
Quality Control, liquid preparations, Ferric Ammonium Citrate, Substandard drugs, IlorinAbstract
Background: The issues of continuous Quality control checks of medicines within our society cannot be over emphasized. These routine checks go a long way in providing information about the quality and efficacy of medicines being sold in the pharmaceutical market
Objectives: This work focused on physical, chemical and microbiological quality control analysis of different brands of liquid preparations containing Ferric Ammonium citrate as one of its active ingredients marketed in Ilorin, Kwara State. It also examines the effect of the concentration of iron content of blood tonic on some physical parameters of the different brands of blood tonic
Methods: A total of seventeen brands of liquid preparations containing Ferric Ammonium citrate as one of its active components was sourced from twenty major registered Pharmacies located in Ilorin, Kwara State. The assay of the Iron content of the samples of blood tonic was carried out using official titrimetric method. Microbiological analysis was done using pour plate method to determine bacterial and fungi counts of samples. Specific gravity and pH of the samples were done using viscometer (Brookfield, England) and digital pH meter (Jenway, UK) respectively.
Results: Analysis showed that four (equivalent to 23.5%) of the samples failed the chemical analysis according to specified standards in some official compendia while microbiological analysis showed that all the samples complied with stated official standards. Results also showed that the quantity of Ferric Ammonium citrate in the various samples had an effect on the pH of the blood tonic (p = 0.005) but does not have any effect on the specific gravity of the various samples used for this study (p= 0.845).
Conclusion: Generally, a substantial number of samples used for the study failed the chemical quality check carried out on them using official methods. Routine checks should be done on these medicines especially by regulatory bodies to ensure that these drugs comply with stated standards.
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