Evaluation Of Some Selected Brands of Iron Containing Liquid Preparations Marketed In Ilorin, Kwara State




Quality Control, liquid preparations, Ferric Ammonium Citrate, Substandard drugs, Ilorin


Background: The issues of continuous Quality control checks of medicines within our society cannot be over emphasized. These routine checks go a long way in providing information about the quality and efficacy of medicines being sold in the pharmaceutical market

Objectives: This work focused on physical, chemical and microbiological quality control analysis of different brands of liquid preparations containing Ferric Ammonium citrate as one of its active ingredients marketed in Ilorin, Kwara State. It also examines the effect of the concentration of iron content of blood tonic on some physical parameters of the different brands of blood tonic

Methods: A total of seventeen brands of liquid preparations containing Ferric Ammonium citrate as one of its active components was sourced from twenty major registered Pharmacies located in Ilorin, Kwara State. The assay of the Iron content of the samples of blood tonic was carried out using official titrimetric method. Microbiological analysis was done using pour plate method to determine bacterial and fungi counts of samples. Specific gravity and pH of the samples were done using viscometer (Brookfield, England) and digital pH meter (Jenway, UK) respectively.

Results: Analysis showed that four (equivalent to 23.5%) of the samples failed the chemical analysis according to specified standards in some official compendia while microbiological analysis showed that all the samples complied with stated official standards. Results also showed that the quantity of Ferric Ammonium citrate in the various samples had an effect on the pH of the blood tonic (p = 0.005) but does not have any effect on the specific gravity of the various samples used for this study (p= 0.845).

Conclusion: Generally, a substantial number of samples used for the study failed the chemical quality check carried out on them using official methods. Routine checks should be done on these medicines especially by regulatory bodies to ensure that these drugs comply with stated standards.


World Health Organization (2007) Quality Assurance of pharmaceuticals: a compendium of guidelines and related materials. Vol. 2, Good manufacturing practices and Inspection. 2nd ed. World H e a l t h O r g a n i z a t i o n . https://apps.who.int/iris/handle/10665/43532 . Accessed February 3, 2021

World Health Organization (2011) WHO's role in measures to ensure the availability of good-quality, safe, efficacious and affordable medical products. http://apps.who.int/gb/ssffc/pdf_files/A_SSFFC_WG 2-en.pdf. 2011.Accessed January 8, 2021

World Health Organization. Quality Control. A v a i l a b l e a t https://www.who.int/medicines/areas/quality_safety/ quality_assurance/control/en/ Accessed February 2, 2021

World Health Organization (2006) Counterfeit M e d i c i n e s : a n u p d a t e o n e s t i m a t e . www.who.int/medicines/services/counterfeit/impact/ TheNewEstimatesCounterfeit . Accessed February 3, 2021

Ghanem N (2019) Substandard and falsified medicines: global and local efforts to address a growing problem. Clinical Pharmacist 11(5). https://doi.org/10.1211/PJ.2019.20206309.

Sammons HM, Choonara I (2017) Substandard medicines: a greater problem than counterfeit medicines? BMJ Paediatrics Open. 1(1):e000007 http://dx.doi.org/10.1136/bmjpo-2017-000007

McNamee T, Hyland T, Harrington J, Cadogan S, Honari B, Perera K, FitzgeraldAP, Perry IJ, Cahill MR (2013) Haematinic deficiency and macrocytosis in middle-aged and older adults. PloS one. 8(11):e77743. https://doi.org/10.1371/journal.pone.0077743.eColle ction2013

DeMaeyer EM, Dallman P, Gurney JM, Hallberg L, Sood SK and Srikantia SG (1989) Preventing and Controlling Iron DeficiencyAnaemia through Primary health care. A guide for health Administrators and p r o g r a m m a n a g e r s . W H O , 9 - 3 6 . https://apps.who.int/iris/handle/10665/39849

United States Pharmacopeia and National Formulary (2012) USP-35-NF30. Rockville: The United States Pharmacopeial convention Inc., 2190

British Pharmaceutical Codex (1973) Formulary. Todd R. G. (ed). London: The Pharmaceutical Press, 741 - 742

B r i t i s h P h a r m a c o p o e i a a n d B r i t i s h Pharmacopoeia Commission (2020). London: Pharmacopeia and The Stationery Office.

National Institutes of Health (NIH). US Department of Health and Human Services. Iron. h t t p s : / / o d s . o d . n i h . g o v / f a c t s h e e t s / I r o n - HealthProfessional/ .Accessed May 4, 2021

Nyanko M (2007) Health Care in Liberia Today: Fake Doctors; Counterfeit Drugs and no alternative for patients. http://www.missiontoliberia.org/health-careliberia.php .Accessed March 24, 2021

Adams UI, Abdullahi U, Saliha BS, Happiness UI (2012) Color Matching Estimation of Iron Concentrations in branded Iron supplements marketed in Nigeria. Advances in Analytical Chemistry of Scientific & Academic Publishing 1:16-23. https://doi.org/10.5923/j.aac.20120201.04

Chemical book (2017) Ammonium ferric citrate. https://www.chemicalbook.com/ChemicalProductPro perty_EN_CB9729858.htm .AccessedApril 13, 2021

FIP Working Party (1975) 2nd report Microbiological purity of non-compulsory sterile pharmaceutical preparations, Pharm. Acta. Helv. 51:33-40.

British Pharmaceutical Codex (1994) 12th edition, Walter L. (ed). London: The Pharmaceutical Press, 511.

Veronica M. and Kennedy DM (2010) Microbial contamination of non-sterile pharmaceuticals in public hospital settings. Therapeutic and clinical risk m a n a g e m e n t 6 : 4 4 3 - 4 4 8 . https://doi.org/10.2147/TCRM.S12253

Oday HK and Dumitru L (2011) Modern aspects regarding the microbial spoilage of pharmaceutical products, Farmacia 59(2):133-146




How to Cite

Abu-Saeed, K., Simon, P. P., & Jamiu, M. O. (2023). Evaluation Of Some Selected Brands of Iron Containing Liquid Preparations Marketed In Ilorin, Kwara State: https://doi.org/10.51412/psnnjp.2023.27. The Nigerian Journal of Pharmacy, 57(2), 672–678. Retrieved from https://psnnjp.org/index.php/home/article/view/491