Silicified Sorghum Bicolor Starch Enhanced Disintegration Of Directly Compressed Ibuprofen Tablet Formulations
Keywords:
Silicified sorghum starch, Co-processing, Enhanced functionality, Directly compressible disintegrant, Ibuprofen tabletsAbstract
Background: Often, excipients have to be modified to enhance their functionality. Co-processing is a method of excipient modification which provides a synergy of functionality improvements and requirements. Sorghum starch (Uss) was co- processed with colloidal silica (Cs) to obtain silicified sorghum starch (sSS) which was evaluated as a directly compressed disintegrant(DCD) in ibuprofen tablets in comparison with silicified microcrystallinecellulose BP(Prosolv(c)).
Method: The Uss was co-processed with Cs at different concentrations to obtain sss containing Uss:Cs at ratios of 95:5,97:3 and 98:2 respectively.The Uss and sSS powders were characterized using FTIR spectroscopy, density measurements, angle of repose, Carr's Index and Hausner's ratio. Different sSS batches (or Prosolv(c)) were incorporated as DCD at 10—25 %w/w in ibuprofen tablet formulations. Tablets were analyzed for tensile strength and friability, and also analyzed using disintegration test.
Results: The Use had characteristic FTIR peaks at 3416.87 cm ' and 2930.98 cm ', while sSS had peaks at 1151.79 cm-' and 1097.62 cm ' and the highest particle density. Tapped densities were 0.69+0.08 gcm , 0.57a0.11 gcm ', 0.68+0.01 gcm , 0.64+0.06 gem ' and 0.69+0.02 gem for Uss, Prosolv”, sSS(95:5), sSS(97:3) and sSS(98:2) respectively. Hauner's ratio ranked Uss the highest. Tablets containing Uss and Sss had lower tensile strengths and were more friable than tablets containing Prosolv(c) and had comparable disintegration times at high concentrations.
Conclusion: Silicification enhanced the powder and disintegrant properties of sorghum starch with better results achieved as the concentration of silicon dioxide was increased.
References
Gu FX , Andrew RK, Wang Z, Alexis F, Nissenbaum EL, Robert SH, Omid SL and Farokhzad C (2007)
Targeted nanoparticles for cancer therapy. Nano Today 2 (3): 14—21
Wang J, Lin S andYang Y, (2017) Medication adherence and its influencing factors of community multimorbidity patients. Chinese Gen Pract 20:23
Sampath-kumar KP, Bhowmik D, Srivastava S, Paswan S and Dutta A.S. (2012): Sustained Release
Drug Delivery System Potential. Journal of Pharma Innovation. 1(2): 48-60
Kolawole SA, Igwemmar C and Bello HA (2013) Comparison of the physicochemical properties of
starch from ginger (Zingiber officinale) and maize (Zea mays). Int J Sc Res 2(11): 71-75.
Paterson AH, Bowers JE and Rokhsar DS (2009) The Sorghum bicolor genome and the diversification
of grasses. Nature 457: 551-556
Boudries N, Belhaneche N, Nadjemi B, Deroanne C Mathlouthi M, Roger B and Sindic M (2009). Physicochemical and functional properties of starches from sorghum cultivated in the Sahara of Algeria. J Carbpol 78(3): 475-480.
Alebiowu G and ltiola OA (2002) Compressional characteristics of native and pregelatinized forms of Sorghum, plantain and corn starches and the mechanical properties of their tablets. Drug Dev Ind Pharm 28 (6): 663-672.
Ali TM and Hasnain A (2014) Morphological, physicochemical, and pasting properties of modified white sorghum (Sorghum bicolor) starch. Int. J Food Prop.17(3): 523- 535.
Adetunji OA, Odeniyi MA and ltiola OA (2007) Effects of white trifoliate yarn and corn starches on the mechanical and release properties of chloroquine phosphate tablets. J Pharm Res 6 (2): 54-59.
Olowosulu AK, Oyi AR, Isah AB and Ibrahim MA (2011) Physicochemical characterization and tabletting properties of starac 955 and starac 9010 - new co-processed starch- based excipients. Nig J Pharm Sci 10 (2):57—69
Sofowora A (1993) Phtochemical tests. In: Medicinal Plants and Traditional Medicine in Africa. Spectrum Books Ltd., Ibadan, Nigeria, 146-211.
Santos H, Veiga F, Pina M and Sousa EJ (2005) Compaction, compression and drug release properties of diclofenac sodium and ibuprofen pellets comprising xanthan gum as a sustained release
agent. Int J Pharm 295: 15—27.
Shivaraju VK and Appukuttan SV (2018). The influence of bound water on the FTIR characteristics of starch and starch nanocrystals obtained from selected natural sources. https://doi.org/10.1002/star. 201 700026. Assessed 08 September, 2018
Punit PS and Rajashree CM (2008) Development and evaluation of artemether taste masked rapid disintegrating tablets with improved dissolution using solid dispersion technique. AAPS Pharm Sci Tech 9:494- 500
Khadka P, Ro J, Kim H, Kim I, Kim JT, Cho JM, Yun G and Lee J ( 2014) Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian J Phar Sc 9: 304-316
Wray PE (1992) The physics of tablet compaction revisited. Drug Dev Ind Pharm. 18(6):627-658.
Okunlola A and Odeku OA (2009) Compressional characteristics and tableting properties of starch obtained from four Dioscorea species. Farmacia 57(6):756—770.
Adetunji OA, Odeniyi MA and ltiola OA (2015) Characterisation and controlled release properties of Entandophragma angolense gum in Ibuprofen matrix tablets. Farmacia 63 (1): 57-64.
Copley M (2008) A test of quality: Manufacturing Chemist 1 1: 31-33.
Thalberg K and Axelsson A (2004) Comparison of the different flowability tests for powders for inhalation. Powder Tech 146(3): 206-213.
Gohel MC, Sumitra GM (2002) Modulation of active pharmaceutical material release from a novel tablet in capsule system containing an effervescent blend. J Cont Rel 79(1-3):157-164
Sheskey PJ, Robb RT and Moore RD (1995) Effects of lubricant level, method of mixing and duration of mixing on a controlled release matrix tablet containing hydroxypropyl methylcellulose. Drug Dev Ind Pharm 21(19):2151-2165.
British Pharmacopeia (2009) The Pharmaceutical Press, Her Majesty's Stationery Office. London.
Bakre LG and Jaiyeoba KT (2009) Evaluation of a new tablet disintegrant from dried pods of Abelmuscus esculentus. Asian J P Cli Res 2(3):74-84.
Adenuga YA (2008) Comparative evaluation of the binding properties of two species of khaya gum
polymer in paracetamol tablet formulation. Pharm Dev Tech 473-480.
Ayorinde JO, Odeniyi MA and ltiola AO (2012) Evaluation of pharmaceutical and chemical equivalence of selected brands of diclofenac sodium tablets. East Central Afr. Journal of Pharmaceutical Sciences, 15:3-9
