Silicified Sorghum Bicolor Starch Enhanced Disintegration Of Directly Compressed Ibuprofen Tablet Formulations


  • Oladapo Adetunji Department of Pharmaceutics & Industrial Pharmacy,
  • Mutiat O. Olawumi Department of Pharmaceutics & Industrial Pharmacy,
  • John Ayorinde Department of Pharmaceutics & Industrial Pharmacy,


Silicified sorghum starch, Co-processing, Enhanced functionality, Directly compressible disintegrant, Ibuprofen tablets


Background: Often, excipients have to be modified to enhance their functionality. Co-processing is a method of excipient modification which provides a synergy of functionality improvements and requirements. Sorghum starch (Uss) was co- processed with colloidal silica (Cs) to obtain silicified sorghum starch (sSS) which was evaluated as a directly compressed disintegrant(DCD) in ibuprofen tablets in comparison with silicified microcrystallinecellulose BP(Prosolv(c)).

Method: The Uss was co-processed with Cs at different concentrations to obtain sss containing Uss:Cs at ratios of 95:5,97:3 and 98:2 respectively.The Uss and sSS powders were characterized using FTIR spectroscopy, density measurements, angle of repose, Carr's Index and Hausner's ratio. Different sSS batches (or Prosolv(c)) were incorporated as DCD at 10—25 %w/w in ibuprofen tablet formulations. Tablets were analyzed for tensile strength and friability, and also analyzed using disintegration test.

Results: The Use had characteristic FTIR peaks at 3416.87 cm ' and 2930.98 cm ', while sSS had peaks at 1151.79 cm-' and 1097.62 cm ' and the highest particle density. Tapped densities were 0.69+0.08 gcm , 0.57a0.11 gcm ', 0.68+0.01 gcm , 0.64+0.06 gem ' and 0.69+0.02 gem for Uss, Prosolv”, sSS(95:5), sSS(97:3) and sSS(98:2) respectively. Hauner's ratio ranked Uss the highest. Tablets containing Uss and Sss had lower tensile strengths and were more friable than tablets containing Prosolv(c) and had comparable disintegration times at high concentrations.

Conclusion: Silicification enhanced the powder and disintegrant properties of sorghum starch with better results achieved as the concentration of silicon dioxide was increased.

Author Biographies

Oladapo Adetunji , Department of Pharmaceutics & Industrial Pharmacy,

Faculty of Pharmacy, University of Ibadan, Nigeria and Centre for Drug Discovery, Development and Production, University of Ibadan, Nigeria

Mutiat O. Olawumi, Department of Pharmaceutics & Industrial Pharmacy,

Faculty of Pharmacy, University of Ibadan, Nigeria

John Ayorinde, Department of Pharmaceutics & Industrial Pharmacy,

Faculty of Pharmacy. University of Ibadan, Nigeria


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How to Cite

Adetunji , O. ., O. Olawumi, M. ., & Ayorinde, J. . (2018). Silicified Sorghum Bicolor Starch Enhanced Disintegration Of Directly Compressed Ibuprofen Tablet Formulations. The Nigerian Journal of Pharmacy, 52(2). Retrieved from