Problems Of Pharmaceutical Production In Nigeria L. Use Of Cassava Starch In Preparation Of Acetylsalicylic Acid 300mg Tablets

Abstract

Cassava starch has not yet achieved a wide spread pharmacopoeal acceptance compared to maize, rice and wheat starches, hence its application in the pharmaceutical industry is still so limited. ln West Africa, particularly in Nigeria Cassava is in mass production as well as a popular food stuff for the natives. It was thought advisable to extract starch from Cassava flour and to use it in the preparation of Acelylsalicylic Acids Tablets, testing its disintegration capacity, as well as its effects on the other physical properties of the tablets. Maize starch was used for comparison. Effect of using different concentrations of Cassava starch as a disintegrant on the physical parameters of Aspirin Tablets was also considered. Effect of Aspirin Granules fineness on the efficacy of Cassava as compared to maize starch was evaluated. From the results so far obtained Cassava starch can be used as a disintegrant and lubricant in the production of Aspirin Tablets and emphasis should be laid on using pure starch, right percentage concentration and suitable compression force to ensure that the tablets produced pass all the necessary physical tests.

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