Effect Of Binder And Disintegrant Concentration On The Dissolution Rate Of Medicaments From Tablet Formulations.

Abstract

The separate effects of varying the concentrations of sorghum and maize starch when used as tablet binder and a disintegrant on the dissolution rate of acetylslicylic acid tablets have been investigated. The dissolution rate of tablets decreased with increasing binder concentration and a direct correlation was observed betweendisintegrant concentration and dissolution rate. Acetylsalicylic acid tablets formulated from sorghum starch had shorter disintegration times and higher dissolution rates than those formulated from maize starch under the same experimental conditions.

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