The Survival of some Free-Living Microorganisms in Four Frequently Dispensed Liquid Pharmaceutical Preparations

Abstract

The ability of some free-living organisms which were isolated from tap water to survive and if possible proliferate in four different liquid pharmaceutical preparations was exarnined. These preparations were challenged with suspensions of bacterial cells whose viability over a 28-day period was monitored by taking viable counts at four-day intervals. Some of the organisms not only survived in the preparations throughout the period‘ of the experiment. but also showed appreciable increase in viable count. On the other hand, some of the organisms employed in this experiment lost their viability very rapidly and could not be detected in the preparations after only four days.

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