An Evaluation Of Some Commercial Brands Ofampicilin Capsules Available In Nigeria

Abstract

Ten commercial brands of ampicillin capsules available locally were subjected to weight variation, uniformity of content, disintegration time and dissolution rate tests. The methods used were those recommended in the United States Pharrnacopoiea (U. S.P) and the British Pharmacopoiea (B.P) with slight modifications in some tests. Considerable variations in these parameters were observed from brand to brand. Some brands-failed some of the tests and passed others. A particular, brand was found to have an average ampicillin content of only 73.6% while, the 90% dissolution of the active drug from another brand was not achieved even after the end of an hour. However, a few of the brands passed in all the tests.

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