Effect of Ethanol Root Extract of Calliandra Portoricensis on the Pharmacokinetic fate of Glibenclamide in Rats
https://doi.org/10.51412/psnnjp.2022.37
Keywords:
herb-drug interaction, Calliandra portoricensis, glibenclamide, PharmacokineticsAbstract
Background: Concomitant administration of herbs with conventional drugs may cause pharmacokinetic modification of the drugs, leading to drug toxicity or therapeutic failure. The observed use of Calliandra portoricensis (Jacq.) Benth in diabetic patients on glibenclamide has aroused interest and its possible influence on the pharmacokinetics of glibenclamide was investigated.
Methods: The dried root of Calliandra portoricensis was pulverized and extracted in 90% ethanol to obtain the crude extract used in this study. After 10 h overnight fast, 30 rats previously acclimatized were given glibencalmide (10 mg/kg) orally. Following a 3-week washout period, the rats were given ethanol root extract of C. portoricensis (500 mg/kg) for 5 days followed by glibenclamide (10 mg/kg). In both studies, blood samples were collected from 0 - 48 h post-dosing and assayed for the concentration of glibenclamide using a well-validated HPLC method and the Pharmacokinetic parameters computed.
Results: The Cmax, AUC0-∞ were significantly lowered (P<0.05) in the co-administered group, which resulted in a decrease in bioavailability. The Kel, Vd, Tmax and MCR were higher in the combination group (P<0.05). Thus suggests that concomitant use of C. portoricensis may have influenced the absorption of glibenclamide thus resulting in decreasedAUCan ; also, increase in Vd may have caused increase in the clearance.
Conclusion: The interaction between glibenclamide and C. portoricensis may be attributed to the presence of some metal ions in the plant. Thus, caution is advised in the concurrent use of these remedies.
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