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Background: Nanotechnology is currently being explored as a more efficient tool in drug delivery. The production of chitosan from crustacean shells, lobsters, and shrimps, is associated with several drawbacks. The study is aimed at evaluating drug delivery potentials of chitosan from different wild edible Nigerian mushrooms.
Methods: Chitosan were prepared from the mushrooms by deproteinisation and deacetylation of chitin. Drug delivery potentials of chitosan isolated from different edible wild Nigerian mushrooms was done using standard methods.
Results: The percentage yield of the chitosan revealed that Hericium erinaceus had 61.11±0.01 followed by Pleurotus tueragium with 52.15± 0.01while Cantharelles cibarius had 11.77±0.03 and was followed by Laccaria laccata with 7.18±.0.01. The In-vitro loading capacity was 5-35% and the entrapment efficiency of the chitosan beads with ampicillin at physiological temperature and pH at concentration of 0.05 and 0.1 gave the highest value that compared favorably with each other while at other concentrations, standard and Cantharelles cibarius had high entrapment efficiency. The results of in-vitro releasing capacity indicated that there was an increased release of the ampicillin with time from 5 - 30 minutes and that the ampicillin-loaded formulation obtained after encapsulation exhibited a sustained release behavior in both standard and the mushroom chitosan beads with a steady rise in
Conclusion: Mushrooms are potential sources of chitosan and that the isolated chitosan from mushrooms could be use as a vehicle for drug delivery in biological systems.
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