Investigation Into The Effects Of Some Binders On Tablet Properties Using Trend Analysis

Authors

  • E. O. Akala Department of Pharmaceutics, University Ife, (Now Obafeml Awolowo University), Ile-Ife, Nigeria
  • F. O. Adewole Department of Pharmaceutics, University Ife, (Now Obafeml Awolowo University), Ile-Ife, Nigeria
  • O. O. Komolafe Department of Pharmaceutics, University Ife, (Now Obafeml Awolowo University), Ile-Ife, Nigeria
  • T. O. Ogundlpe Department of Pharmaceutics, University Ife, (Now Obafeml Awolowo University), Ile-Ife, Nigeria
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Abstract

Modem techniques in drug product design and process development demand the establishment of the relationship between independent variables (formulation and process variables) and the response variables (tablet properties) by means of a mathematical equation. Such equations are often valuable when various factors are to be combined to optimize a particular drug product property. A technique for describing the response to varying levels of a quantitative factor is trend analysis (determination of regression model through the use of orthogonal polynomials). The technique is equivalent to using the method of least squares, but it has the advantage that while tests are carried out to determine whether or not statistically significant differences exist at among the various factors and levels of factor(s) of interest,information about the functional relationship between treatments and response can be found. Moreover, the use of orthogonal polynomials permits the test of each regression coefficient in the polynomial equation independently of the others and thus helps to select the terms that should be included in the regression model.

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Published

2022-10-01

How to Cite

Akala, E. O. ., Adewole, F. O. ., Komolafe, O. O. ., & Ogundlpe, T. O. . (2022). Investigation Into The Effects Of Some Binders On Tablet Properties Using Trend Analysis. The Nigerian Journal of Pharmacy, 23(1). Retrieved from https://psnnjp.org/index.php/home/article/view/269