Development of Zinc and Copper- carboxylate metal-organic frameworks (MOFs) as potential drug Carriers
Keywords:
Metal-organic frameworks, Loading, Solvent-free, Drugs, X-ray powder diffractionAbstract
Introduction: Metal-organic frameworks (MOFs) are promising drug nano-vehicles due to their biocompatibility and high porosity. This study explored the feasibility of synthesizing Copper-isonicotinate and Zinc-fumarate mechanochemically and utilizing the compounds for the loading of Ibuprofen and Urea respectively.
Methods: Zinc-fumarate [Zn(fum)(H2O)2] and Copper-isonicotinate [Cu(INA)2].H2O] metal-organic frameworks (MOFs) were synthesized by solvent-free mechanochemical technique. These compounds were characterized using elemental analysis; UV-Vis and Fourier transform infrared (FT-IR) Spectroscopies and X-ray powder diffraction (XRPD). The MOFs were investigated for the loading of Ibuprofen and Urea respectively based on their porosities for better drug interaction and high loading using UV-VIS spectroscopy.
Results: The synthesized Zinc-fumarate [Zn(fum)(H2O)2] exhibited a very high drug loading capacities of 98 ± 1.45 wt% of Ibuprofen while the synthesized Copper-isonicotinate [Cu(INA)2].H2O] exhibited a slightly high drug loading capacities of 44 ± 0.95 wt% of Urea.
Conclusion: Zinc-fumarate and Copper-isonicotinate MOFs are potential candidates for drug loading.
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