The Effects Of Repeated Chloroquine Administration In Growing Female Rats.

Abstract

The effects of repeated administration of 40mg Kg -1 chloroquine diphosphate, given by daily intraperitoneal injections for 21 dayshave been examined in growing female rats. Some factors contributing to the observed effects were investigated. Chloroquine depressed the body weight of the rats which retarded their growth and caused stunting, as assessed from femur length and circumferential growth. Chloroquine reduced the dry mass of organs examined without an appreciable effect on their water content. There were some behavioural disturbances observed after chloroquine administration.

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