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Whereas colloidal solutions of hydrophilic polymers (e.g. HPMC) are frequently used as binders in wet ranulation procedures, the hydrophobic polymers (e.g. certain acrylate methacrylate copolymers) do not ﬁnd similar application readily because of their insolubility in water and the fact that organic solvents are expensive, inﬂammable, and toxic. In this study an aqeous based granulation ﬂuid of the arcylate-methacrylate copolymers was prelpared by a coarcevation technique and used as binder, with the hope that inclusion of a hydrophobic polymer in tablets by this technique may minimize the moisture uptake potential of the tablets.
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