A New High Performance Liquid Chromatographic Method For Simultaneous Determination Of 1-And 2-Naphtols In Urine

Authors

  • Osarerhin E. Izedonmwen Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, lle-lfe, Nigeria.
  • A. O. Ogundaini Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, lle-lfe, Nigeria.
  • F. O. Ogungbamila Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, lle-lfe, Nigeria.
  • J. A. Owa Department of Paediatrics, Faculty of Health Sciences, Obafemi Awolowo University. lle-lfe. Nigeria.
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Abstract

A sensitive, specific and rapid high-performance liquid chromatographic (HPLC) procedure has been developed for the detection and determination of urine levels of 1- and 2- naphtols. Urine samples were adjusted to pH 1.5 and extracted with dichloromethane. HPLC on a Micropak CN-10 column with a fixed wavelength U.V. detector (254nm) and hexane: dichloromethane: isopropyl alco- hol (89:10:1) as solvent system allowed the measurement of 1-naph- thol at l00nng ml-I and 2-naphtholat 500ng ml-l levels.

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Published

1992-10-01

How to Cite

Izedonmwen, O. E. ., Ogundaini, A. O. ., Ogungbamila, F. O. ., & Owa, J. A. . (1992). A New High Performance Liquid Chromatographic Method For Simultaneous Determination Of 1-And 2-Naphtols In Urine. The Nigerian Journal of Pharmacy, 23(3). Retrieved from https://psnnjp.org/index.php/home/article/view/267

Issue

Vol. 23 No. 3 (1992): Nigerian Journal of Pharmacy

Section

Research Article

License

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.