Formulation Studies On The Hot Water Leaf Extract Of Ficus Sur (Moraceae): Effect Of Lnsoluble Dlluents On Compaction Characteristics.

Abstract

Kunle O. O.

Department of Pharmaceutical Technology and Raw Material Development

National Institute for Pharmaceutical Researchabd Development P.M.B 21 Abuja, Nigeria

ABSTRACT

The hot water extract at  the leaves at Fiscus sur, a saprophytic plant widely available in most parts at Atrica and used in GIT  disorders was formulated into tablets. The compaction behaviour at the  extract with 2 insoluble diluents - heavy magnesium carbonate and aerosil was studied using the Heckel equation. The results showed that the equation was usetul in explaining the compaction characteristics with most at the tormulations having type B detormation characteristics, an indication that they would produce strong compacts. ln some cases the presence at the extract changed the type B deformation pattern at heavy magnesium carbonate to type C. The particle size at the granulates was also usetul in explaining some at the observations.