Effects Of Co-Administration Of Ascrobic Acid On Sulphadoxine/Pyrimethamine In Mice Infected With Plasmodium Berghei

L.O. Iniaghe; P. M. Emeka; H. Ogbunuga

Effects Of Co-Administration Of Ascrobic Acid On Sulphadoxine/Pyrimethamine In Mice Infected With Plasmodium Berghei

Authors

L.O. Iniaghe Department of Pharmacology and Toxicology, University of Benin
P. M. Emeka Department of Pharmacology, King Faisal University, AL-AHSA, Saudi Arabia
H. Ogbunuga Department of Applied Biochemistry, Nnamdu Azikiwe University, Awka

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Abstract

Background: Co-administration of antioxidants in antimalarial therapy is a common practise in some pans of Nigeria. Antioxidants such as ascorbic acid and vitamin E are often included in malaria therapy; this is aimed at reducing the cytotoxic effects of free radicals generated during malaria infection or from anti-malarial agents. There is therefore the need to evaluate the beneﬁts or risks of this practice. The effect of ascorbic acid on mice infected with Plasmodium berghei and treated with sulphadoxine/pyrimethamine was evaluated in this Study.

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Published

2012-08-01

How to Cite

Iniaghe , L., Emeka , P. M., & Ogbunuga , H. (2012). Effects Of Co-Administration Of Ascrobic Acid On Sulphadoxine/Pyrimethamine In Mice Infected With Plasmodium Berghei. The Nigerian Journal of Pharmacy, 45(1). Retrieved from https://psnnjp.org/index.php/home/article/view/161