Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000
Keywords:
Ibuprofen, Solid Dispersion, Binary Carrier system, Solubility, DissolutionAbstract
Background: Adequate drug bioavailability is a major problem in most solid dosage formulations. Recent works reported enhanced solubility and dissolution using a carrier. This study was carried out to enhance the solubility and dissolution of ibuprofen using a binary carrier system.
Method: Solid dispersions (SD) of ibuprofen were prepared using PEG 6000 and D (-) mannitol in difffferent ratios (1:0:4, 1:1:3, 1:2:2, 1:3:1, and 1:4:0) by the fusion method.
Results: Percentage yield of SD was between 96% and 99% and content analysis revealed 100 % drug content. All batches of SD showed better solubility characteristics than Ibuprofen alone or its physical mixtures. The SD batch 3, ratio 1:2:2 with equal amount of PEG and mannitol possessed the best solubility characteristic and drug release profifile with T50% at 17 min. FTIR spectral and DSC thermograms of SDs showed no interaction between the carriers and ciproflfloxacin.
Conclusion: The SD3 formulated with 20 % ibuprofen, 40 % mannitol and 40 % PEG 6000 possessed better solubility and dissolution is therefore recommended
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