Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000

Authors

  • Abiodun O. Shittu Department of Pharmaceutics and Industrial Pharmacy, https://orcid.org/0000-0003-1838-9299
  • Ngaitad S. Njinga Department of Pharmaceutical and Medicinal Chemistry,
  • Susanna D. Orshio Department of Pharmaceutics and Industrial Pharmacy,

Keywords:

Ibuprofen, Solid Dispersion, Binary Carrier system, Solubility, Dissolution
         Abtract Views | PDF Download: 408 / 274 / 0

Abstract

Background: Adequate drug bioavailability is a major problem in most solid dosage formulations. Recent works reported enhanced solubility and dissolution using a carrier. This study was carried out to enhance the solubility and dissolution of ibuprofen using a binary carrier system.

Method: Solid dispersions (SD) of ibuprofen were prepared using PEG 6000 and D (-) mannitol in difffferent ratios (1:0:4, 1:1:3, 1:2:2, 1:3:1, and 1:4:0) by the fusion method.

Results: Percentage yield of SD was between 96% and 99% and content analysis revealed 100 % drug content. All batches of SD showed better solubility characteristics than Ibuprofen alone or its physical mixtures. The SD batch 3, ratio 1:2:2 with equal amount of PEG and mannitol possessed the best solubility characteristic and drug release profifile with T50% at 17 min. FTIR spectral and DSC thermograms of SDs showed no interaction between the carriers and ciproflfloxacin.

Conclusion: The SD3 formulated with 20 % ibuprofen, 40 % mannitol and 40 % PEG 6000 possessed better solubility and dissolution is therefore recommended

Author Biographies

Abiodun O. Shittu, Department of Pharmaceutics and Industrial Pharmacy,

Faculty of Pharmaceutical Sciences, University of Ilorin

Ngaitad S. Njinga, Department of Pharmaceutical and Medicinal Chemistry,

Faculty of Pharmaceutical Sciences, University of Ilorin.

Susanna D. Orshio, Department of Pharmaceutics and Industrial Pharmacy,

Faculty of Pharmaceutical Sciences, University of Ilorin.

References

Patel SK, Kumar D, Waghmode AP, and Dhabale AS (2011). Solubility of Ibuprofen using Hydrotropic Agents; International Journal of Pharmaceutical and Life Sciences 2(2):542-545.

Sandip S, Mukesh B, Ashish R, Gautam M and Mahesh N (2013) An overview on the mechanisms of solubility and dissolution rate enhancement in solid dispersion. International Journal of PharmTech Research, 5(1): 31-39.

Patel SK, Kumar D, Waghmode AP and Dhabale AS (2011). Solubility of Ibuprofen using Hydrotropic Agents; Int. J. of Pharmaceutical and Life Sciences 2(2):542-545.

Leuner C and Dressman J (2000). Improving drug solubility for oral delivery using solid dispersions.European Journal of Pharmacy and Biopharmacy 50: 47-60. http://doi.org/10.5281/zenodo.4446489

Dhirendra K, Lewis S, Udupa N and Atin K (2009). Solid dispersion: A review. Pakistan Journal of Pharmaceutical Sciences 22(2): 234-246. http://doi.org/10.5281/zenodo.4446489

Sharma M, Garg R. and Gupta G.D (2013). Formulation and Evaluation of Solid Dispersion of Atorvastatin Calcium; Journal of Pharmaceutical and Scientific Innovation, 2 (4):73-81. http://doi.org/10.7897/2277-4572.02459

Sridhar I, Doshi A, Joshi B, Wankhede V, and Doshi J (2013). Solid Dispersions: An Approach to Enhance Solubility of Poorly Water Soluble Drug; Journal of Scientific and Innovative Research 2 (3): 685-694

Das A, Nayak AK, Mohanty B and Panda SB (2011). Solubility and dissolution enhancement of etoricoxib by solid dispersion technique using sugar carriers. ISRN Pharmaceutics, Art. No. 819765. http://doi.org/ 10.5402/2012/820653

Nadia S, Marzan J and Naz HH (2011). Dissolution profile of ibuprofen solid dispersion prepared with cellulosic polymers and sugar by fusion method. Stamford Journal of Pharmaceutical Sciences, 4(1): 31 - 37. https://doi.org/10.3329/sjps.v4i1.8864

Hasnain MS and Nayak AK (2012). Solubility and dissolution enhancement of ibuprofen by solid dispersion technique using PEG 6000-PVP K30 Combination carrier. Bulgarian Journal of Science Education 21(1):118-132.

Ofokansi KC, Kenechukwu FC, Isah AB, Allagh TS and Anumeka OO (2012) Formulation and evaluation of solid dispersions based on Eudragit RS 100 and PEG 8000 for improved delivery of trandolapril. African Journal of Pharmaceutical Research and Development 4(1): 38-42.

Dabbagh MA and Taghipour B (2007). Investigation of Solid Dispersion Technique in Improvement of Physicochemical Characteristics of Ibuprofen Powder. Iranian Journal of Pharmaceutical Sciences 3: 69-76

Saquib M and Amit K (2012). Solubility and dissolution enhancement of ibuprofen by solid dispersion technique using peg 6000-pvp k 30 combination carrier. Chemistry: Bulgarian Journal of Science Education, Volume 21.

Shittu AO, Oyeyiola RW, Stanislaus NN and Afosi AB (2019). De sign, Formul a tion, and Characterization of Ibuprofen Polyethylene Glycol (6000) Solid Dispersion. West African Journal of Pharmacy 30 (2): 52-65.

Goracinova K, Klisarova L, Simov A, Fredro-Kumbaradzi E, Petrusevska-Tozi L (1996). Preparation, physical characterization, mechanisms of drug/polymer interactions and stability studies of controlled release of solid

dispersion granules containing weak base as active substance. Drug Development and Industrial Pharmacy 22:255-62.

Shah S, Joshi S, Lin S and Medan PL(2012) Preparation and characterization of spironolactone and solid dispersions using hydrophilic carriers. Asian Journal of Pharmaceutical Sciences 7(1):40-49.

Adeli E and Mortazavi SA (2014). Design, formulation and evaluation of azithromycin binary solid dispersions using Kolliphor series for the solubility and in vitro dissolution rate enhancement. Journal of. Pharmaceutical. Investigation. 44 (2) 119-131.

Downloads

Published

2022-03-25

How to Cite

O. Shittu, A. ., S. Njinga, . N. ., & D. Orshio, S. . (2022). Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000. The Nigerian Journal of Pharmacy, 56(1), 109–118 | https://doi.org/10.51412/psnnjp.2022.12. Retrieved from https://psnnjp.org/index.php/home/article/view/116