TY - JOUR AU - Yohana Izam, Yocy AU - Chinenye Aguiyi, John PY - 2021/09/30 Y2 - 2024/03/28 TI - Hepatoprotective effect of the ethanolic leaf extract of Carissa edulis (vahl) apocynaceae on carbon tetrachloride induced liver toxicity in rats JF - The Nigerian Journal of Pharmacy JA - PSNNJP VL - 55 IS - 2 SE - Articles DO - UR - https://psnnjp.org/index.php/home/article/view/87 SP - 15-23 | https://doi.org/10.51412/psnnjp.2021.9 AB - <p><strong>Background: </strong>There are claims by herbalist and even indigenes of Plateau state on the efficient use of&nbsp;<em>Carissa edulis</em> in the management of liver diseases. This work was aimed at assessing these claims to determine the hepatoprotective effects of<em>Carissa edulis</em>.</p><p><strong>Methods: </strong>The ethanolic leaf extract of <em>Carissa edulis </em>was scrutinized for hepatoprotective activity against Carbon tetrachloride (CCl4 ) induced liver damage. Biochemical parameters were studied to&nbsp;assess the hepatoprotective activity of the ethanolic extract in serum. Total Bilirubin, Total Protein,&nbsp;Albumin, Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase, Total Cholesterol,&nbsp;Triglyceride and High-Density Lipoprotein were determined to assess the effect of the extract on CCl4&nbsp;induced hepatic damage. Other test conducted include, liver antioxidant test like glutathione,&nbsp;malondialdehyde, superoxide dismutase, catalase and histopathological assessment of liver sections..</p><p><strong>Results: </strong>The markers in the animals treated with CCl4 showed elevated concentration indicating severe hepatic damage by CCl4. A significant decrease in serum markers was observed in rats treated with plant&nbsp;extract signifying the effect of the plant extract in restoring normal functional ability of the hepatocytes.</p><p><strong>Conclusion: </strong>These results imply that the ethanolic leaf extract of Carissa edulis has a protective effect&nbsp;against CCl4 induced hepato-cellular injury.</p> ER -