TY - JOUR AU - Mainah, Manasseh M AU - David, Kenneth B PY - 2023/04/01 Y2 - 2024/03/29 TI - Retrospective Study on the Antibiotic Sensitivity Pattern of Bacterial Isolates in Patients with Chronic Suppurative Otitis Media at the National Ear Care Centre Kaduna, Nigeria: https://doi.org/10.51412/psnnjp.2023.13 JF - The Nigerian Journal of Pharmacy JA - PSNNJP VL - 57 IS - 1 SE - Articles DO - UR - https://psnnjp.org/index.php/home/article/view/447 SP - 525-531 AB - <p><strong>Background: </strong>The management of Chronic Suppurative Otitis Media primarily employs the use of&nbsp;antimicrobial agents. In light of&nbsp; varying susceptibility of the infective organisms associated with&nbsp;Chronic Suppurative Otitis Media to antimicrobials; with respect to&nbsp; geography, patient peculiarities&nbsp;and rise in antimicrobial resistance, it is important to study these patterns of susceptibility/resistance&nbsp; to&nbsp;aid in rational use of antimicrobials. Knowing these patterns would help curtail excessive (most times,&nbsp;unjustififiable) use of&nbsp; antimicrobials, leading to reduced side effffects and cost. Hence, this study is aimed&nbsp;at studying these patterns at the National Ear Care&nbsp; Centre, Kaduna, Nigeria.&nbsp;</p><p><strong>Methods: </strong>The study was conducted in the National Ear Care Centre, Kaduna. It involved a&nbsp;retrospective review of Culture and&nbsp; sensitivity results of patients across all age groups who presented&nbsp;to the National Ear Care Centre, Kaduna, within a period of 2 years&nbsp; (February 2018 – January 2020).&nbsp;Total number of 315 cases identifified, with 253 case fifiles retrieved. Sensitivity data (for cases with&nbsp;such) were extracted and entered into Microsoft Excel 2010 for descriptive analysis.&nbsp;</p><p><strong>Results: </strong>Of the 315 patients who presented with CSOM, only 253 (80.32%) case fifiles were accounted&nbsp;for. Patient ages ranges from 0.2&nbsp; years to 78 years (Mean age 22.8 years), prevalence highest amongst&nbsp;age group 0-5 years (n=69, 21.9%). Clinical Isolates were&nbsp; <em>Pseudomonas aeruginosa </em>(n=32, 50.0%),&nbsp;<em>Staphylococcus aureus </em>(n=20, 31.25%), <em>Streptococcus specie </em>(n=5, 7.81%), <em>Candida specie </em>(n=3,&nbsp;4.69%), <em>Proteus specie </em>(n=2, 3.13%), <em>Klebsiella specie </em>(n=1, 1.56%) and <em>Escherichia coli </em>(n=1,&nbsp;&nbsp;1.56%); <em>Staphylococcus aureus</em>, <em>Pseudomonas specie</em>, <em>Streptococcus specie</em>, <em>Proteus specie </em>and&nbsp;<em>Candida specie </em>isolates were found to predominate in male. Antibiotic&nbsp; sensitivity was greatest with the&nbsp;Quinolones (89.4%), amongst all the recommended antimicrobials for treating Chronic Suppurative&nbsp;Otitis Media, which are involved in this study.&nbsp;</p><p><strong>Conclusion: </strong>This study showed that both gram positive and gram negative bacteria are signifificantly&nbsp;involved in the aetiology of&nbsp; Chronic Suppurative Otitis Media with single bacteria specie involved in&nbsp;majority of cases. Treatment is best guided by Culture and&nbsp; sensitivity data. However, the broad&nbsp;spectrum antibiotics (Quinolones) are the best option for empirical treatment.&nbsp;&nbsp;</p> ER -