TY - JOUR AU - O. Shittu, Abiodun AU - S. Njinga, Ngaitad AU - D. Orshio, Susanna PY - 2022/03/25 Y2 - 2024/03/28 TI - Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000 JF - The Nigerian Journal of Pharmacy JA - PSNNJP VL - 56 IS - 1 SE - Articles DO - UR - https://psnnjp.org/index.php/home/article/view/116 SP - 109-118 | https://doi.org/10.51412/psnnjp.2022.12 AB - <p><strong>Background: </strong>Adequate drug bioavailability is a major problem in most solid dosage formulations. Recent works reported enhanced solubility and dissolution using a carrier. This study was carried out to enhance the solubility and dissolution of ibuprofen using a binary carrier system. </p><p><strong>Method: </strong>Solid dispersions (SD) of ibuprofen were prepared using PEG 6000 and D (-) mannitol in difffferent ratios (1:0:4, 1:1:3, 1:2:2, 1:3:1, and 1:4:0) by the fusion method.</p><p><strong>Results: </strong>Percentage yield of SD was between 96% and 99% and content analysis revealed 100 % drug content. All batches of SD showed better solubility characteristics than Ibuprofen alone or its physical mixtures. The SD batch 3, ratio 1:2:2 with equal amount of PEG and mannitol possessed the best solubility characteristic and drug release profifile with T50% at 17 min. FTIR spectral and DSC thermograms of SDs showed no interaction between the carriers and ciproflfloxacin.</p><p><strong>Conclusion: </strong>The SD3 formulated with 20 % ibuprofen, 40 % mannitol and 40 % PEG 6000 possessed better solubility and dissolution is therefore recommended</p> ER -