@article{Dorathy Udem_Umale Adikwu_Nkechukwu Ikegbunam_Chukwuneke Udem_2021, title={Formulation and evaluation of capsules and suppositories containing Gongrenema Latifolium}, volume={55}, url={https://psnnjp.org/index.php/home/article/view/90}, abstractNote={<p><strong>Introduction</strong>: Earlier studies have been done on <em>Gongronema latifolium </em>(GL) for anti-diabetic effect using animal model. However, the extracts have bitter taste. This study focused on the formulation and evaluation of solid dosage forms namely capsules and suppositories.</p> <p><strong>Method: </strong>Purified GL were used in formulation of capsules and suppositories.The capsules were evaluated for various physico-chemical properties such as weight uniformity, disintegration time and dissolution test. Physical properties of suppositories were also assessed. Investigation on anti-diabetic effects of capsules and suppositories of purifified <em>Gongronema latifolium </em>on Streptozotocin-induced diabetic rats was carried out.</p> <p><strong>Results</strong>: Weight uniformity tests of the capsules showed percentage deviation of less than 10%. Disintegration of the capsules was within 2 min. Drug release profile showed that peak drug release occurred at 12 min. Physical properties of suppositories were satisfactory. The antidiabetic effect of capsules was 52+ 11.82 %. C-peptide (pM) of GL purifified capsules was 115.76 +1.54 respectively. Blood glucose of diabetic guinea pig was not significantly reduced when varying concentrations of GL suppositories were administered.</p> <p><strong>Conclusion</strong>: Capsules and suppositories passed compendia requirements, while purifified <em>Gongronema </em><em>latifolium </em>capsules demonstrated signifificant anti-diabetic activities unlike the suppositories. Suppository is not an ideal dosage form for <em>Gongronema latifolium </em>anti-diabetic herb.</p>}, number={2}, journal={The Nigerian Journal of Pharmacy}, author={Dorathy Udem, Ngozi and Umale Adikwu, Michael and Nkechukwu Ikegbunam, Moses and Chukwuneke Udem, Samuel}, year={2021}, month={Sep.}, pages={35–43 | https://doi.org/10.51412/psnnjp.2021.11} }